Since upgrading to Mac OS X 10.4, I had noticed some changes to iSync. I had noticed that the .Mac icon in iSync doesn't do anything. Also, the iSync menu item can not initiate a sync with my phone.
Chris Holland wrote the same thing on The Apple Blog. But he also mentioned Sync Now, "re-adds" the feature to sync your devices without launching iSync. The program works perfectly
Technorati Tags: iSync, Mac OS X